The Brush tool in photoshop, is the most widely used in the digital art industry. It is also one of the most diverse tools i have ever come across in not just digital art but art in general. There are millions of different settings to apply to brushes including brush shapes to add. You can change the opacity of the brush to create certain tones and shades of colour which all add up to define shape to the object of which you are painting. You can also use pen pressure settings to replicate actual brushes in reality.
In my own work i have used the Photoshop brush many times, All my work in photoshop i have used the brush at one point, even if it is to simply add a streak of shadow across the image. Also adding highlights and flashes of colour to photos. But i have mainly used it for painting as you would in reality. Creating images from scratch onto a blank canvas i feel my knowledge of using the brush tool is very nourished.
Below an image of the brush tool in use on Photoshop,
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